Single-cell RNA-seq of the Developing Cardiac Outflow Tract

Cardiac outflow tract (OFT) is a major hotspot for congenital heart diseases (CHDs). Approximately 30% of CHDs involve abnormalities in OFT development, which constitute a large class of CHDs, namely OFT malformations. A thorough understanding of the cellular diversity, transitions and regulatory networks of normal OFT development is essential to decipher the etiology of OFT malformations.

We preformed single-cell transcriptomic sequencing of 55,611 mouse OFT cells from three successive developmental stages... »»» more